LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty
نویسندگان
چکیده
منابع مشابه
KISS1 Gene Polymorphisms in Korean Girls with Central Precocious Puberty
Kisspeptin/G-protein couple receptor-54 (GPR54) system plays a key role in the activation of the gonadotropic axis at puberty. Central precocious puberty (CPP) is caused by the premature activation of hypothalamic gonadotropin-releasing hormone secretion. This study was aimed to identify KISS1 gene variations and to investigate the associations between KISS1 gene variations and CPP in Korean gi...
متن کاملLIN28B polymorphisms are associated with central precocious puberty and early puberty in girls
PURPOSE Single-nucleotide polymorphism (SNP) markers within LIN28B have been reported to be related to the timing of pubertal growth. However, no study has investigated the frequency of genetic markers in girls with precocious puberty (PP) or early puberty (EP). This study aimed to determine the frequency of putative genetic markers in girls with PP or EP. METHODS Genomic DNAs were obtained f...
متن کاملIdiopathic central precocious puberty in girls: presentation factors
BACKGROUND It is sometimes difficult to distinguish between premature thelarche and precocious puberty in girls who develop breasts before the age of 8 years. We evaluated the frequencies of the signs associated with breast development and the factors influencing the presentation of girls with idiopathic central precocious puberty (CPP). METHODS 353 girls monitored 0.9 +/- 0.7 year after the ...
متن کاملGenetic Variations of the KISS1R Gene in Korean Girls with Central Precocious Puberty
The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study aimed to identify the kisspeptin receptor (KISS1R) gene variations and to investigate the associations between these variations and central precocious puberty (CPP). Korean girls with CPP (n = 194) and their healthy controls (n = 99) were included in this study. T...
متن کامل[Central precocious puberty].
Central precocious puberty, defined as the onset of puberty before the age 8 years in girls and 9 years in boys, results from a premature activation of gonadotropin-releasing hormone neurons in the hypothalamus. This condition is characterised by early pubertal changes, acceleration of growth velocity, and rapid bone maturation that often result in reduced adult height. It may be either idiopat...
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ژورنال
عنوان ژورنال: BMC Research Notes
سال: 2011
ISSN: 1756-0500
DOI: 10.1186/1756-0500-4-363